Description

Amoxycillin is a Beta –Lactam antibiotic in the amino penicillin family. It is one of the most frequently prescribed antibiotics worldwide for controlling mild to moderate Infections. Amoxycillin is a broad Spectrum antibiotic with bactericidal action against Gram Positive and Gram Negative bacteria. Amoxycillin acts by inhibiting synthesis of bacterial cell wall.

Amoxycillin is effective against the following organisms;

Gram –Positive Organisms

Alpha and Beta Hemolytic Streptococci, Clostridium species except C difficile, Streptococcus pneumonia, Corynebacterium diphtheria, Streptococcus fecalis , Bacillus anthracis, Non beta Lactamase producing Staphylococci.

Gram Negative Organisms

Haemophilus Influenzae, Salmonella species, Shigella species, Neisseria gonorrhoea, N meningitis, Branhamella catarrhalis, Proteus mirabilis, E coli.

Clavulanic Acid is beta-lactamase inhibitor to overcome certain types of antibiotic resistance. It is derived from Streptomyces clavuligerus. It has a betalactam ring that is characteristic of betalactam antibiotics. . Clavulanic acid is betalactamase enzyme Inhibitor.

Clavulanic acid has no antimicrobial activity. Its sole purpose is to prevent the inactivation of betalactam antibiotics by betalactamase enzyme. Since Clavulanic acid has a betalactam ring similar to the one of Amoxycillin, the betalactamase enzyme secreted by bacteria attaches to this ring to spare the one on Amoxycillin. Thus Amoxycillin is able to attack the pathogen and overcome the resistance due to betalactamase produced by these bacteria.

Contraindications

Amoxycillin should not be administered to patients who are hypersensitive to Penicillins.

Indications

• Respiratory Tract Infections
• Urinary Tract Infections
• Acute Exacerbations of chronic Bronchitis
• Acute Otitis Media
• Acute Sinusitis
• Septic Abortions
• Community Acquired Pneumonia

Dosage

Adults: One tablet BID.

Children: Children over 2 years;

25/3.6 mg/kg/day (Amoxycillin / Clavulanate ) in mild to moderate infections.

45/6.4 mg/kg/ day (Amoxycillin / Clavulanate ) in severe infections.

Presentation

INCLAB 625 Alu-Alu strips of 6 tabs

INCLAB Dry syrup Bottle of 3.3g to be reconstituted to 30ml