Honeysip Suspension

Dextromethorphan

is an antitussive agent which acts centrally and elevates the threshold for coughing. It is about equal to codeine in depressing the cough reflex. In therapeutic dosage dextromethorphan does not inhibit ciliary activity. Dextromethorphan is rapidly absorbed from the gastrointestinal tract and exerts its effect in 15 to 30 minutes. The duration of action after oral administration is approximately three to six hours. Dextromethorphan is metabolized primarily by liver enzymes.

Chlorpheniramine maleate

Competitively antagonizes histamine at H1 receptor sites. It is readily absorbed and is 72% protein bound. Reduces cholinergic nerve transmission and also reduces the nasal secretion.Chlorpheniramine maleate is metabolized predominantly in the liver, but also in the lung and kidneys. Caution should be exercised while driving or operating heavy machinery as it may cause drowsiness.

BITTERNESS MASKING

To mask the intensely bitter taste of Dextromethorphan hydrobromide it is adsorbed into an ion exchange resin complex. When Honeysip suspension is swallowed, bitter taste is not felt because the resin complex does not release the drug at salivary pH. When it comes in contact with acidic environment of stomach, the complex is broken down releasing the drug for absorption.

This technique makes Honeysip the best tasting cough syrup without bitterness.

Indications

• Symptomatic relief from non-productive, dry and irritating cough
• Upper respiratory symptoms such as irritation of throat
• Cough associated with common cold and upper respiratory tract infections

Contraindications

• Hypersensitivity to any ingredients
• Neonates
• Premature infants
• Nursing mothers

Precautions

History of asthma, narrow angle glaucoma, gastrointestinal obstruction, uncontrolled diabetes.

Dosage

Adults -10 ml 3-4 times a day

Children: 6-12 yrs – 5 ml 3-4 times a day

Children : 2-6 yrs – 2.5 ml 3-4 times a day

Presentation Bottle of 60 ml and 100 ml