Also known as acetaminophen is a widely used analgesic and antipyretic. After oral administration it is rapidly absorbed by the GI tract. Paracetamol is metabolised primarily in the liver.
Paracetamol- Relives pain & reduces fever by acting centrally. It selectively inhibits COX-3, and has additional weak activity on COX-2 in brain.
Is a non-steroidal anti-inflammatory drug used to treat pain; it is typically prescribed for oral administration. The absorption of the drug is more than 90% and peak serum levels are attained within 2 hours. Mainly metabolised in the liver. Mefenamic Acid reduces fever by blocking COX-2 as well as COX-3.
Rationale for combination
- Mefenamic Acid inhibits primarily COX-2 that is present in Hypothalamus
- Paracetamol inhibits primarily COX-3 in other parts of brain (except hypothalamus)
- Mefenamic acid blocks the effects of PGE (made by both COX-2 as well as COX-3) on EP receptor in brain
Advocated for Symptomatic relief of Fever and Pain in children.
Dose of in children
- 6 months to 2 years: 1 tsf upto 3 times as necessary
- 2 to 5 years: 1 to 2 tsf thrice daily as necessary
- 5 to 9 years: 2 tsf thrice daily as necessary
Bottle of 60 ml in a delicious Mango flavour